解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::A very simple analytical procedure with dimethylmethylene blue as photometric reagent was applied for the evaluation of glycosaminoglycan (GAG) urinary excretions and concentrations in both sexes, calcium oxalate stone formers, and a control group. The GAG concentrations varied significantly in stone formers (males an...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188306
更新日期:1994-01-01 00:00:00
abstract::We present a 57-year-old man with end-stage renal failure due to chronic glomerulonephritis, who had been on hemodialysis for 13.5 years and had suffered from recurrent painful swelling of the left leg for 4.7 years. A diagnosis of deep venous thrombosis was made by the phlebography. Coagulation studies showed decreas...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187835
更新日期:1994-01-01 00:00:00
abstract::Complement factor D, a complement system serine protease, circulating in vivo as its active form, accumulates in patients with chronic renal failure. The pathophysiological role of this active protease in these patients was examined by studies on activities of excess factor D on 10 synthetic peptide substrates for som...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187824
更新日期:1994-01-01 00:00:00
abstract::The expression of the adhesion molecules LFA-1 (CD11a-CD18), Mac-1 (CD11b-CD18), and LAM-1 on predialysis and intradialysis neutrophils (PMN) was analyzed by flow cytometry in 10 chronic hemodialysis patients (CHD) and compared with age-matched normal controls. All patients were dialyzed either with a polyacrylonitril...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188255
更新日期:1994-01-01 00:00:00
abstract::The methodology for the collection, extraction, separation and measurement of urinary angiotensin II [the octapeptide, ANG(1-8)] is described. To determine the origin of urinary ANG(1-8), mean arterial pressure, renal hemodynamics and the arterial, renal venous and urinary concentrations of ANG(1-8) were examined prio...
journal_title:Nephron
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1159/000188215
更新日期:1994-01-01 00:00:00
abstract::We examined the ultrastructure of the bovine glomerular basement membrane (GBM) and tubular basement membrane (TBM) using ultra-high-resolution scanning electron microscopy after conductive staining without metal coating. Purified basement membranes (BMs) were obtained by sonication and acellular BMs by detergent trea...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187800
更新日期:1994-01-01 00:00:00
abstract::To clarify whether the changes of parathyroid size have any correlations with the long-term prognosis of calcitriol pulse therapy, we examined the time course of serum levels of parathyroid hormone (PTH) and size of parathyroid glands in 14 chronic dialysis patients during and after the oral calcitriol pulse therapy. ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000188261
更新日期:1994-01-01 00:00:00
abstract::Copper (Cu) and zinc (Zn) were measured in urine, serum and tissues from rats with nephrotic syndrome (NS) induced with a single subcutaneous dose of puromycin aminonucleoside (PAN; 15 mg/100 g BW). Control animals were pair-fed. Urine was collected daily, and the rats were sacrificed on day 10. PAN-nephrotic rats had...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187772
更新日期:1994-01-01 00:00:00
abstract::Gastrointestinal infection with verotoxin-producing Escherichia coli (VTEC) has been strongly implicated in the etiology of the hemolytic uremic syndrome (HUS), the leading cause of pediatric acute renal failure. The binding of fluorescein-conjugated VT1 overlaid on to frozen human renal sections has been examined. Se...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187761
更新日期:1994-01-01 00:00:00
abstract::Chronic cyclosporine nephrotoxicity is characterized morphologically by cortical interstitial fibrosis. The most important collagens involved in renal fibrosis are collagen types I and III. In order to estimate the synthesis of type III and type I collagens, we analyzed serum levels of the amino-terminal propeptide of...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187929
更新日期:1994-01-01 00:00:00
abstract::The biochemistry and function of vanadate and its possible role in health as well as in disease remains one of the most fascinating stories in biology. This review has surveyed the pertinent literature regarding its effect in the normal kidney and other tissues. While inhibition of the Na(+)-K+ ATPase enzyme was the f...
journal_title:Nephron
pub_type: 社论,评审
doi:10.1159/000187913
更新日期:1994-01-01 00:00:00
abstract::A patient with collagenofibrotic glomerulopathy associated with hepatic persinusoidal fibrosis is described. Renal biopsy revealed that the glomerular tufts contained homogeneous material that was proved by electron microscopy to be collagen fibers. The material was reactive to anti-type III collagen monoclonal antibo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187180
更新日期:1993-01-01 00:00:00
abstract::Cadmium-induced renal effects were followed (1989) in 16 workers previously exposed to cadmium, who had been shown 5 years earlier to have had tubular damage; all but 1 worker had persistent tubular damage (beta 2-microglobulin > 60 micrograms/mmol creatinine). The mean glomerular filtration rate (GFR) decreased from ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187282
更新日期:1993-01-01 00:00:00
abstract::A 51-year-old Japanese man was referred for the evaluation of persistent hyponatremia. The serum sodium level remained around 120 mmol/l despite mild water restriction. His past history included chronic alcoholism, myocardial infarction and lumbar disc herniation. Carbamazepine (200 mg, b.i.d.) has been used for more ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187295
更新日期:1993-01-01 00:00:00
abstract::In order to elucidate the mechanism of peritoneal dialysis fluid inhibition of cell functions, laboratory-prepared fluids were used to investigate the specific influences of low pH and high lactate concentration on neutrophil viability, phagocytosis, respiratory burst activation and leukotriene B4 (LTB4) generation. I...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187485
更新日期:1993-01-01 00:00:00
abstract::Dopexamine hydrochloride is a synthetic dopamine analogue recently developed to improve myocardial and renal performance in patients suffering from low cardiac output states. The present study was designed to assess the pharmacological profile and the anatomical localization of [3H]-dopexamine binding sites within the...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187518
更新日期:1993-01-01 00:00:00
abstract::A study was conducted to determine whether intraperitoneal and oral administration of formalin-fixed gram-negative bacteria induced immunohistologically and ultrastructurally evident glomerular deposition of IgA and C3 in C3H/HeN mice. Separate treatments with strains of Pseudomonas aeruginosa, Escherichia coli, Haemo...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187474
更新日期:1993-01-01 00:00:00
abstract::Radial arterial spasm in uremic patients undergoing construction of internal arteriovenous (AV) dialysis fistulas was investigated transcutaneously using ultrasonic Doppler flowmetry. In 5 of 15 patients, radial arterial blood flow was significantly decreased 5 min after anastomosing the radial cephalic vein with the ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187390
更新日期:1993-01-01 00:00:00
abstract::Normal and streptozotocin diabetic rats were subjected to ischemic injury by unilateral renal artery occlusion for 60 min. The cortical and the medullary oxygen consumption (QO2) in the postischemic and the control, contralateral nonischemic, kidneys were measured 1 h, 1 day, and 1, 2 and 4 weeks for normal rats and 1...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187367
更新日期:1993-01-01 00:00:00
abstract::Previous work has shown that cigarette-smoking affects platelets and endothelium in men and women without renal failure. The present study compared 10 male habitual smokers receiving maintenance hemodialysis for chronic renal failure with 11 healthy male habitual smokers before and after controlled cigarette-smoking a...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187354
更新日期:1993-01-01 00:00:00
abstract::Hypercalciuria and nephrocalcinosis are not uncommon in patients with Wilson's disease but have only once been reported as the presenting sign. We diagnosed Wilson's disease in a 17-year-old male patient 6 years after his first episode of gross hematuria and 2 years after detection of hypercalciuria and nephrocalcinos...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187530
更新日期:1993-01-01 00:00:00
abstract::Conjugated diene fatty acids (CDFA) were evaluated by second derivative spectrophotometry in the plasma and adipose tissue of 42 chronic renal failure (CFR) patients in conservative treatment, 40 patients treated by hemodialysis (HD) with cuprophane, cellulose acetate or hemophan, 29 treated by hemodiafiltration (HDF)...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187520
更新日期:1993-01-01 00:00:00
abstract::Circumstantial evidence that pIgA has a key role in glomerular injury of IgAN is now strong. Although the answers to the questions posed in this review are necessarily incomplete, they do indicate that (1) pIgA is a major component of mesangial IgA. (2) circulating pIgA is increased and this pIgA is particularly enhan...
journal_title:Nephron
pub_type: 社论
doi:10.1159/000187509
更新日期:1993-01-01 00:00:00
abstract::The specific lipid alterations in plasma and four different tissues, as well as the activities of plasma lecithin-cholesterol acyltransferase (LCAT) and tissue lipolytic enzymes were determined in experimental nephrotic and control rats. In nephrotic rats, the cholesterol level in the heart was significantly increased...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187323
更新日期:1993-01-01 00:00:00
abstract::The accumulation in blood plasma and efficiency of hemodialysis of pyrimidine compounds (orotic acid, orotidine, pseudouridine, uridine, thymine) as well as uric acid and creatinine in 23 patients with chronic renal failure (CRF) was investigated. As a reference, the analysis of the above metabolites in the plasma of ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187313
更新日期:1993-01-01 00:00:00
abstract::ExHC rats were bred from the Sprague-Dawley strain and are highly susceptible to dietary hypercholesterolemic stimuli. Although chemical and histological examination of the aorta from ExHC rats fed a diet containing 3% cholesterol, 0.6% sodium cholate and 15% olive oil (high-cholesterol diet, HCD) has been reported, r...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187216
更新日期:1993-01-01 00:00:00
abstract::In order to evaluate effects of metabolic acidosis on glucose metabolism in uremia, we studied, by an intravenous glucose tolerance test (IVGTT), 46 patients with severe chronic renal failure divided into three groups according to their blood bicarbonate (BB) values: group A formed by 15 patients without or with light...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187141
更新日期:1993-01-01 00:00:00
abstract::The present study was aimed to determine the effect of caffeine on the development of renal hypertension. Two-kidney, 1-clip (2K1C) hypertension and deoxycorticosterone acetate (DOCA, 200 mg/kg, subcutaneous implantation)-salt (0.9% NaCl drinking) hypertension were instituted in Sprague-Dawley rats. They were then gro...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187574
更新日期:1993-01-01 00:00:00
abstract::The relationship between glycosaminoglycans and beta 2-microglobulin, glycosaminoglycans and N-acetyl-beta-D-glucosaminidase as well as the relationship between the chondroitin sulfate/heparan sulfate ratio and SDS electrophoresis in the urine of subjects from the endemic area of Balkan nephropathy was studied in orde...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187564
更新日期:1993-01-01 00:00:00
abstract::There is already a considerable amount of evidence suggesting that fibronectin (Fn) plays an important role in the pathogenic process in some forms of glomerulonephritis (GN). It has been postulated that Fn may participate in the progression or regression of glomerular diseases. The Fn is presented in the kidney as a ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187249
更新日期:1993-01-01 00:00:00
abstract::To avoid the use of aluminium as a phosphate binder, patients on CAPD who were stable were dialysed against a peritoneal dialysis fluid which was magnesium free. A mixture of calcium and magnesium carbonate was used as a phosphate binder over a period in excess of 1 year. Vitamin D analogues were used in the majority....
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187238
更新日期:1993-01-01 00:00:00
abstract::Mysterious deaths of archeologists after opening Egyptian tombs have been suspected to be secondary to inhalation of mycotoxin, however, the hypothesis has never been verified. Recently, we observed a case of acute renal failure (ARF) undeniably due to inhalation of ochratoxin of Aspergillus ochraceus. After spending ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187411
更新日期:1993-01-01 00:00:00
abstract::To determine the role of vasoactive peptides such as endothelin (ET), calcitonin gene-related peptide (CGRP) and human atrial natriuretic peptide (hANP) in the regulation of blood pressure in uremic patients, and to determine the effect of various types of dialyzer membranes on hemodialysis (HD)-induced changes in pla...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187399
更新日期:1993-01-01 00:00:00
abstract::The effects of acute beta 2-type adrenoreceptor activation with intravenous albuterol on plasma and urinary sodium, potassium, calcium, magnesium, phosphate and lithium were investigated in 9 volunteers during acute hydration. When compared with the control infusion with inactive vehicle, beta 2-type adrenoreceptor ac...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187403
更新日期:1993-01-01 00:00:00
abstract::The effect of dilazep, an adenosine potentiator and platelet aggregation inhibitor, on experimental diabetic nephropathy was investigated in spontaneous diabetic Chinese hamster. Prediabetic animals, 8 weeks of age, were divided into two groups. In one group, 5 mg/kg dilazep was injected i.p. once a day. In the other ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000187453
更新日期:1993-01-01 00:00:00
abstract::A four-year-old male with steroid refractory nephrotic syndrome was found to have diffuse deposition of alpha 2-macroglobulin (alpha 2M) in the glomeruli which showed diffuse mesangial proliferation and partial hyalinization by light microscopy. Camostat mesylate, a commercially available synthetic proteinase inhibito...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186874
更新日期:1992-01-01 00:00:00
abstract::The authors report on the presence of anti-HCV antibodies in a uremic chronic (UC) patient population after 6 months and 1 year with regard to certain selective preventive measures. The nonincreased number of HCV-positive subjects among the UC population could lead to the conclusion that the risk of environmental spre...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186941
更新日期:1992-01-01 00:00:00
abstract::HCV is seen as an emergent problem in Dialysis Units; in fact, the patients of these centers are at high risk for blood-transmitted infections, through coming microepidemies. For this reason and using the same method, we have studied the prevalence of anti-HCV and virus-derived hepatitis in a dialytic population of 10...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186922
更新日期:1992-01-01 00:00:00
abstract::136 patients on hemodialysis, 89 males and 47 females, were studied; we evaluated the index of hepatic function (SGOT and SGPT) and antibodies against HCV. We observed 42 cases of increased transaminases classified as non-A, non-B (NANB) hepatitis. Antibodies against HCV were present in 40 patients. Among 42 patients ...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186903
更新日期:1992-01-01 00:00:00
abstract::We investigated the incidence of painless (silent) myocardial ischemia, manifested as S-T segment deviation, by Holter ECG monitoring in patients with chronic renal failure undergoing regular hemodialysis. Forty-five patients underwent Holter ECG monitoring for a continuous 48-hour period covering dialysis and the int...
journal_title:Nephron
pub_type: 杂志文章
doi:10.1159/000186733
更新日期:1992-01-01 00:00:00